Splicing factor SRSF1 promotes breast cancer progression via oncogenic splice switching of PTPMT1

CONCLUSIONS: SRSF1 exerts oncogenic roles in BRCA partially by regulating the AS of PTPMT1, which could be a therapeutic target candidate in BRCA and a prognostic factor in HR+ BRCA patient.PMID:33992102 | DOI:10.1186/s13046-021-01978-8

Source: Clinical Genitourinary Cancer - May 16, 2021 Category: Cancer & Oncology Authors: Jun-Xian Du Yi-Hong Luo Si-Jia Zhang Biao Wang Cong Chen Gui-Qi Zhu Ping Zhu Cheng-Zhe Cai Jing-Lei Wan Jia-Liang Cai Shi-Ping Chen Zhi Dai Wei Zhu Source Type: research