Secretory Galectin-3 promotes hepatic steatosis via regulation of the PPAR γ/CD36 signaling pathway

In conclusion, the present study confirmed the roles of Gal3 in hepatic lipid metabolism in both in vitro and in vivo studies and revealed that Gal3 is a secretory protein that promotes hepatic steatosis through the PPARγ-CD36-dependent pathway, suggesting that targeting Gal3 may represent a potential therapeutic approach for the treatment of NAFLD and related metabolic disorders.PMID:33991615 | DOI:10.1016/j.cellsig.2021.110043

Source: Cellular Signalling - May 15, 2021 Category: Cytology Authors: Huiyuan Yu Fan Yang Wentao Zhong Xin Jiang Fan Zhang Xueying Ji Mengjuan Xue Yixuan Qiu Jiaming Yu Xiaona Hu Jie Chen Zhijun Bao Source Type: research