Early-phase migration dynamics of Echinococcus multilocularis in two mouse strains showing different infection susceptibilities

Int J Parasitol. 2021 May 12:S0020-7519(21)00172-7. doi: 10.1016/j.ijpara.2021.04.001. Online ahead of print.ABSTRACTThe early-phase migration dynamics of Echinococcus multilocularis in the intermediate hosts remain largely unknown. We compared the parasite burden in the intestine, liver and faeces of DBA/2 and C57BL/6 mouse strains using parasite-specific quantitative PCR. Our results indicated that the parasites invaded mainly from the middle segments of the small intestine and completed migration to the liver within 24 h p.i. C57BL/6 mice had lower parasite DNA burdens in the intestine and liver but higher in the faeces than DBA/2 mice, suggesting that parasite invasion of the intestine may be a critical stage regulating E. multilocularis infection in mice.PMID:33991567 | DOI:10.1016/j.ijpara.2021.04.001
Source: International Journal for Parasitology - Category: Parasitology Authors: Source Type: research