Plain packaging 'may help smokers to cut down'

Conclusion This small study showed that priming adult smokers with a picture of a branded cigarette packet causes more of them to seek cigarettes compared with unbranded cigarettes – around 10% more. But this study has problems, meaning we can't really rely on its findings. The biggest of these was fully acknowledged by the study authors themselves. Professor Marcus Munafò, a co-author of the study, explained: "The experimental procedure only modelled the ability of pack stimuli to promote a cigarette-seeking choice. In the natural environment, smoking may be governed by a whole range of factors, including tobacco withdrawal, the presence of other people smoking, time of day, and so on. It is not clear to what extent plain packaging will reduce smoking when these other factors are at play.” The biggest real-world experiment is already happening in Australia, where plain packaging was introduced by law in 2012. The wider evidence showing whether plain packaging reduces smoking-related death and disease in adults or children was not discussed in this study, so we cannot comment. Taken on its own, this specific study adds weak evidence to the debate. There may be stronger evidence elsewhere. On this point, the Addiction journal's editor-in-chief, Professor Robert West, said in the BBC article: "All the pieces are building the same picture, which is that it is going to have a reduction; none of the studies are pointing in the other direction....
Source: NHS News Feed - Category: Consumer Health News Tags: Heart/lungs Cancer Medical practice Mental health Source Type: news

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Luca Mologni Targeted therapy is an effective, rational, and safe approach to solid and hematological tumors treatment. Unfortunately, a significant fraction of patients treated with tyrosine kinase inhibitors (TKI) relapses mainly because of gene amplification, mutations, or other bypass mechanisms. Recently a growing number of papers showed how, in some cases, resistance due to oncogene overexpression may be associated with drug addiction: cells able to proliferate in the presence of high TKI doses become also TKI dependent, undergoing cellular stress, and apoptosis/death upon drug withdrawal. Notably, if a sub-cell...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Conclusions: In this study, we successfully identified 4 DMs, three significant pathways, and a key gene MPO in ESCC, which might play key roles during the occurrence and development of ESCC and could be chosen as good indicators and therapeutic schedule for ESCC.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
Abstract High-throughput drug sensitivity testing provides a powerful phenotypic profiling approach to identify effective drug candidates for individual cell lines or patient-derived samples. Here, we describe an experimental-computational pipeline, named target addiction scoring (TAS), which mathematically transforms the drug response profiles into target addiction signatures, and thereby provides a ranking of potential therapeutic targets according to their functional importance in a particular cancer sample. The TAS pipeline makes use of drug polypharmacology to integrate the drug sensitivity and selectivity pr...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
In this study, we use a multi-scale modeling approach to interrogate the implications of three metabolic scenarios of potential clinical relevance: the Warburg effect, the reverse Warburg effect and glutamine addiction. At the intracellular level, we construct a network of central metabolism and perform flux balance analysis (FBA) to estimate metabolic fluxes; at the cellular level, we exploit this metabolic network to calculate parameters for a coarse-grained description of cellular growth kinetics; an d at the multicellular level, we incorporate these kinetic schemes into the cellular automata of an agent-based model (AB...
Source: PLoS Computational Biology - Category: Biology Authors: Source Type: research
Alcohol content measuring wristbands, smart lighters, nicotine tracking wearables, stop smoking apps, virtual reality therapies, automated messaging platforms are the newest elements in the arsenal of digital health technologies supporting everyone in the fight against addiction to cigarettes, alcohol or drugs. Addiction and dependency ruins lives Once you become addicted, it sticks with you for a long time, if not for life. It doesn’t matter whether it’s about cigarettes, alcohol, medication, drugs, gambling, sex, etc., any of these substances or phenomena could cause you strong dependency and might impact you...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine Future of Pharma Medical Professionals Patients Researchers alcohol cigarette digital health drugs health technology Innovation medication opioid opioid crisis smartphone smartphone apps smoking virtual Source Type: blogs
(University of Pennsylvania School of Medicine) A team of surgeons from the Perelman School of Medicine at the University of Pennsylvania are the first in the world to use a surgical robot to assist with a bilateral free flap breast reconstruction, allowing patients to recover and be discharged more quickly and without the use of addictive narcotic painkillers.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
ConclusionsThe new strategy for esophageal endoscopy has led to an evolutionary change in Japan. The patients with esophageal cancer and head and neck cancer who underwent a second or subsequent endoscopy had lower incidences of smoking and alcohol consumption, although the incidences remained high.
Source: Esophagus - Category: Gastroenterology Source Type: research
You're reading Hypnosis – what’s fact and what’s fiction?, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Hypnosis is a technique that is both widely used and controversial. Many see it as a form of stage entertainment. True hypnosis, however, is very different and has valuable medical and therapeutic benefits, providing effective treatment to a variety of ailments - from anxiety and depression to chronic pain. To help you gain a deeper understanding of hypnosis, let’s look at how it works and unp...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured self improvement health hypnosis pickthebrain Source Type: blogs
Publication date: Available online 29 November 2018Source: Cancer CellAuthor(s): Bin Lu, Olaf Klingbeil, Yusuke Tarumoto, Tim D.D. Somerville, Yu-Han Huang, Yiliang Wei, Dorothy C. Wai, Jason K.K. Low, Joseph P. Milazzo, Xiaoli S. Wu, Zhendong Cao, Xiaomei Yan, Osama E. Demerdash, Gang Huang, Joel P. Mackay, Justin B. Kinney, Junwei Shi, Christopher R. VakocSummaryThe Mixed Lineage Leukemia gene (MLL) is altered in leukemia by chromosomal translocations to produce oncoproteins composed of the MLL N-terminus fused to the C-terminus of a partner protein. Here, we used domain-focused CRISPR screening to identify ZFP64 as an e...
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research
Purpose of review ‘Early-stage’ nonsmall cell lung cancer (NSCLC) refers to stage I and stage II disease, and selected cases of stage IIIA disease where complete tumor resection is feasible. Surgery is the standard treatment for early NSCLC, but the overall 5-year survival remains below 50%. The addition of adjuvant cisplatin-based chemotherapy to surgery improved 5-year survival rates by 5–10%, but no significant therapeutic innovation has been established thereafter. We review recent and ongoing studies looking how immunotherapy may improve the outcome of these patients. Recent findings Antigen-spe...
Source: Current Opinion in Oncology - Category: Cancer & Oncology Tags: LUNG AND MEDIASTINUM: Edited by Robert Pirker Source Type: research
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