Animal Models of Post-Traumatic Epilepsy and their Neurobehavioral Comorbidities

Traumatic brain injury (TBI) is defined as a disruption of brain functioning, or other brain pathology, caused by an external force [1]. The TBI is typically accompanied by one or more clinical signs immediately following the injury; including lost or altered consciousness, amnesia, neurologic deficit, intracranial lesion, and seizures [2]. Seizures produced by TBI can be classified as: (1) acute seizures, which occur less than 24 hours after injury; (2) early seizures, which occur less than 1 week after injury; and (3) late seizures, which occur more than a week after injury and are constituents of a post-traumatic epilepsy (PTE) diagnosis [3-7].
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Source Type: research