Couple: Diacetyl In Microwave Popcorn Caused Permanent Lung Disease

ST. LOUIS - A couple whose lawsuit against popcorn manufacturers was dismissed by an Iowa federal court filed a brief in the Eighth Circuit U.S. Court of Appeals on Feb. 6 contending that their claims for personal injury related to alleged exposure to diacetyl and pentanedione, the chemicals used to make artificial butter flavoring in popcorn, are valid because "it has been proven" that diacetyl can cause the permanent lung disease known as bronchiolitis obliterans (David Stults, et al. v. American Popcorn Company, No. 14-3658, 8th Cir.).
Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal News - Category: Medical Law Source Type: news

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We present here the incidence and long-term outcome of BOS occurring after HSCT in an extended cohort of 110 patients monitored with home spirometry.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Research letters Source Type: research
Purpose of review The current review highlights the most relevant articles on lung infections following hematopoietic stem cell transplantation (HCT) published over the last year. Between 30 and 50% of HCT recipients will develop pulmonary infiltrates. These pulmonary complications may be infectious (caused by virus, bacteria, fungi, or protozoa) or noninfectious (e.g., fluid overload, heart failure, transfusion reactions like transfusion associated lung injury and transfusion-associated circulatory overload, drug reactions, engraftment syndrome, idiopathic pneumonia syndrome, diffuse alveolar hemorrhage, cryptogenic org...
Source: Current Opinion in Organ Transplantation - Category: Surgery Tags: INFECTIOUS COMPLICATIONS IN TRANSPLANTATION: Edited by Shimon Kusne Source Type: research
Pulmonary dysfunction is one of the major causes of non-relapse mortality in patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT). It requires a wide differential diagnosis and has been linked to chemotherapy toxicity, irradiation, infections, immune-induced injury by Graft-versus-Host-Disease (GvHD) and restrictive lung diseases [1,2].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Conclusions Immunomodulation mediated via ECP is a rational therapeutic option that may improve clinical outcomes in patients with BOS, particularly in the context of in-depth patient phenotyping as part of a stratified approach to treatment; good quality randomized controlled trials are needed to confirm observational findings.
Source: Transplantation - Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research
Conclusions We show in this retrospective study that specific donor HLA class II types are important in lung transplantation, because they are associated with either protection from or susceptibility to development of severe BOS.
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Conclusion: ILD was the most common cause of ESLD in patients referred for lung transplantation. The waitlist mortality was highest for patients with bronchiolitis and IPF. Despite having ESLD, very few patients were willing for lung transplantation. Patients willing for lung transplantation died earlier than those who were unwilling.
Source: Lung India - Category: Respiratory Medicine Authors: Source Type: research
Introduction. Chronic lung allograft dysfunction with its clinical correlative of bronchiolitis obliterans syndrome (BOS) remains the major limiting factor for long-term graft survival. Currently there are no established methods for the early diagnosis or prediction of BOS. To assess the feasibility of breath collection as a non-invasive tool and the potential of breath volatile organic compounds (VOC) for the early detection of BOS, we compared the breath VOC composition between transplant patients without and different stages of BOS. Methods. 75 outpatients (25 BOS stage 0, 25 BOS stage 1  + 2, 25 BOS sta...
Source: Journal of Breath Research - Category: Respiratory Medicine Authors: Source Type: research
Abstract Exosomes are extracellular vesicles that express self-antigens (SAgs) and donor human leukocyte antigens. Tissue-specific exosomes can be detected in the circulation following lung, heart, kidney and islet cell transplantations. We collected serum samples from patients who had undergone lung (n=30), heart (n=8), or kidney (n=15) transplantations to isolate circulating exosomes. Exosome purity was analyzed by Western blot, using CD9 exosome-specific markers. Tissue-associated lung SAgs, collagen V (Col-V) and K-alpha 1 tubulin (Kα1T), heart SAgs, myosin and vimentin, and kidney SAgs, fibronectin and ...
Source: Human Immunology - Category: Allergy & Immunology Authors: Tags: Hum Immunol Source Type: research
Community acquired respiratory virus (CARV) infections have been associated with significant acute morbidity and occasional mortality in lung transplant (LTX) recipients. Moreover, there is accumulating evidence that CARV infections may be associated with the development of chronic lung allograft dysfunction (CLAD) (1) for which bronchiolitis obliterans syndrome (BOS) is the most common phenotype although a restrictive phenotype is increasingly recognised (2, 3). CLAD, remains the most important complication limiting the long-term success of lung transplantation and occurs in 50% of recipients within 5 years (4).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
Abstract PURPOSE OF REVIEW: The current review highlights the most relevant articles on lung infections following hematopoietic stem cell transplantation (HCT) published over the last year. Between 30 and 50% of HCT recipients will develop pulmonary infiltrates. These pulmonary complications may be infectious (caused by virus, bacteria, fungi, or protozoa) or noninfectious (e.g., fluid overload, heart failure, transfusion reactions like transfusion associated lung injury and transfusion-associated circulatory overload, drug reactions, engraftment syndrome, idiopathic pneumonia syndrome, diffuse alveolar hemorrhage...
Source: Current Opinion in Organ Transplantation - Category: Transplant Surgery Authors: Tags: Curr Opin Organ Transplant Source Type: research
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