Couple: Diacetyl In Microwave Popcorn Caused Permanent Lung Disease
ST. LOUIS - A couple whose lawsuit against popcorn manufacturers was dismissed by an Iowa federal court filed a brief in the Eighth Circuit U.S. Court of Appeals on Feb. 6 contending that their claims for personal injury related to alleged exposure to diacetyl and pentanedione, the chemicals used to make artificial butter flavoring in popcorn, are valid because "it has been proven" that diacetyl can cause the permanent lung disease known as bronchiolitis obliterans (David Stults, et al. v. American Popcorn Company, No. 14-3658, 8th Cir.).
This study aimed to evaluate a reader-independent quantitative density metric (QDM) derived from CT histograms to associate with CLAD survival. A retrospective study evaluated CT scans corresponding to CLAD onset using pulmonary function tests in 74 patients (23 RAS, 51 BOS). Two different QDM values (QDM1 and QDM2) were calculated using CT lung density histograms. Calculation of QDM1 includes the extreme edges of the histogram. Calculation of QDM2 includes the central region of the histogram. Kaplan-Meier analysis and Cox regression analysis were used for CLAD prognosis. Higher QDM values were significantly associated wit...
Exosomes isolated from serum and broncho-alveolar lavage fluid from lung transplant recipients (LTxR) with bronchiolitis obliterans syndrome (BOS) but not stable LTxR demonstrated expression of donor HLA and lung self-antigens (SAgs), Collagen V (Col-V) and K-alpha 1 Tubulin (K α1T). The goal of this study is to determine the use of exosomes with SAgs as a non-invasive clinical biomarker for LTxR at risk for development of BOS.
Severe acute rejection after lung transplantation increases the risk of bronchiolitis obliterans syndrome with lower patient and graft survival. Many efforts should be addressed to identify biomarkers to minimize acute rejection rate and improve long term graft survival. The CD8 effector memory T cells have been identified as a potential biomarker of acute rejection in patient awaiting for a lung transplantation(1). The aim of this study was to correlate CD8 effector memory T cells (CD8 TEM) with severity of acute rejection.
Cyclosporine delivered directly to the lung allograft by inhalation may benefit patients with bronchiolitis obliterans syndrome (BOS) after lung transplantation.
Chronic lung allograft dysfunction is the major complication after lung transplantation (LTx) that results from a complex interplay of inflammatory and alloimmune factors, culminating in parenchymal and/or airway fibrosis with obliterative bronchiolitis (OB). The lung allograft is constantly exposed to noxious stimuli from the external environment via the airways. We hypothesized that repeated administration of lipopolysaccharide (LPS) would augment alloimmunity and trigger chronic rejection and fibrosis in a mouse minor alloantigen-mismatched orthotopic lung transplant model (C57BL/10 [B10] → C57BL/6 [B6]).
Complement activation is a fundamental mechanism for host defense and modulation of environmental stress following lung transplantation. We recently found that intracellular C3 has additional functions in mediating CD4+T cell homeostasis and cytokine production. However, the role of intracellular C3 in airway epithelial cells (AEC) has not been defined. Here we examined intracellular C3 in the setting of oxidant-induced stress, which is implicated in ischemia-reperfusion injury (IRI) and bronchiolitis obliterans syndrome (BOS).
In this study, we hypothesized that the inhibition of Th1 response by overexpressing SOCS3 attenuates the development of OB in a model of murine heterotopic tracheal transplantation (HTT).
Circulating exosomes isolated from lung transplant recipients (LTxR) with bronchiolitis obliterans syndrome (BOS), but not stable, contained donor HLA and lung self-antigens (SAgs), Collagen V (Col-V) and K α1Tubulin (Kα1T), supporting that exosomes induce immune responses leading to BOS. We defined the differences in phenotypic and molecular characteristics of exosomes (BOS vs stable) towards determining their immunogenicity.
Introduction: Respiratory complications of Hematopoietic Stem Cell Transplantation (HSCT), both allogeneic and autologous, comprise the majority of its morbidity and mortality. Chronic Graft Versus Host Disease (cGVHD) is a multisystem disorder that is a common complication of allogeneic Hematopoietic Stem Cell Transplantation (HSCT). Bronchiolitis Obliterans Syndrome (BOS) considered part of the spectrum of cGVHD pulmonary manifestations, affect 5.5% of transplant recipients. The prognosis of BOS remains poor.
Pulmonary graft versus host disease (GVHD), manifest as bronchiolitis obliterans, bronchiectasis and pulmonary fibrosis, is a serious complication of haematopoietic stem cell transplantation (HSCT) causing respiratory failure and death. There are limited therapeutic options for severe cases other than lung transplantation (LTx) but