Couple: Diacetyl In Microwave Popcorn Caused Permanent Lung Disease

ST. LOUIS - A couple whose lawsuit against popcorn manufacturers was dismissed by an Iowa federal court filed a brief in the Eighth Circuit U.S. Court of Appeals on Feb. 6 contending that their claims for personal injury related to alleged exposure to diacetyl and pentanedione, the chemicals used to make artificial butter flavoring in popcorn, are valid because "it has been proven" that diacetyl can cause the permanent lung disease known as bronchiolitis obliterans (David Stults, et al. v. American Popcorn Company, No. 14-3658, 8th Cir.).
Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal News - Category: Medical Law Source Type: news

Related Links:

This article is protected by copyright. All rights reserved. PMID: 30303525 [PubMed - as supplied by publisher]
Source: Clinical and Developmental Immunology - Category: Allergy & Immunology Authors: Tags: Clin Exp Immunol Source Type: research
AbstractPurpose of ReviewSynthesize recent developments in the understanding of chronic lung allograft dysfunction (CLAD) epidemiology, pathophysiology, outcomes, and treatments with a focus on the classification of CLAD into restrictive allograft syndrome (RAS) and from bronchiolitis obliterans syndrome (BOS).Recent FindingsChronic lung allograft dysfunction (CLAD) remains the leading cause of long-term morbidity and mortality in lung transplant recipients. Despite the lack of progress on improving outcomes, significant progress has been made in better characterizing the disease ’s clinical and pathologic diversity....
Source: Current Respiratory Care Reports - Category: Respiratory Medicine Source Type: research
Lung transplantation (LTx) recipients have 1-, 5-, and 10-year unadjusted survival rates of 80%, 54%, and 32%, respectively.1 Chronic lung allograft dysfunction (CLAD) causes most deaths after the first post-transplant year,1 –3 and most CLAD has an obstructive phenotype known as bronchiolitis obliterans syndrome (BOS).4 Obliterative bronchiolitis (OB), the histologic hallmark of BOS, consists of a fibrotic luminal obliteration of the respiratory and terminal bronchioles.5 The patchy nature of OB reduces the diagnostic sensitivity of transbronchial lung biopsies.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
Pulmonary compromise has been shown to significantly contribute to nonrelapse mortality after hematopoietic stem cell transplantation (HSCT) [1-4]. The etiology of these pulmonary complications includes intrapulmonary causes of fibrosis and toxicities from treatment regimens or infections (ie, restrictive lung disease), graft-versus-host disease (GVHD) or bronchiolitis obliterans syndrome (BOS) (ie, obstructive lung disease), and vascular abnormalities (eg, pulmonary hypertension), as well as extrapulmonary causes, such as weakness or sclerodermatous GVHD.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Pulmonary compromise has been shown to significantly contribute to non-relapse mortality after hematopoietic stem cell transplantation (or HSCT).1-4 The etiology of these pulmonary complications includes intrapulmonary causes of fibrosis and toxicities from treatment regimens or infections (restrictive lung disease), graft-versus-host disease or bronchiolitis obliterans syndrome (obstructive lung disease), and vascular abnormalities (e.g. pulmonary hypertension), as well as extrapulmonary causes such as weakness or sclerodermatous GVHD.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
There is a need for non-invasive parameters that are sensitive to the development of the bronchiolitis obliterans syndrome (BOS) in lung transplantation (LTx) patients. We studied whether the pulmonary diffusi...
Source: Respiratory Research - Category: Respiratory Medicine Authors: Tags: Research Source Type: research
The 21st Transplant Registry Report summarizes data from pediatric lung and heart/lung transplant recipients and their donors for transplants that occurred through June 30, 2017. This year's report focuses on an overall theme of multiorgan transplantation. In addition to reporting key data for all adult lung and heart-lung transplant recipients, we report transplant types, historical trends, geographical associations, indications, donor and recipient characteristics and transplant outcomes including rejection burden, bronchiolitis obliterans syndrome (BOS), and survival for multiorgan transplant recipients.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
The 21st Transplant Registry Report summarizes data from pediatric lung and heart ‒lung transplant recipients and their donors for transplants that occurred through June 30, 2017. This year's report focuses on an overall theme of multiorgan transplantation. In addition to reporting key data for all pediatric lung and heart–lung transplant recipients, we report transplant type s, historical trends, geographical associations, indications, donor and recipient characteristics, and transplant outcomes, including rejection burden, bronchiolitis obliterans syndrome (BOS), and survival for multiorgan transplant recipients.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
CONCLUSIONS In selected lung transplant recipients, early sirolimus-based immunosuppression is safe and associated with beneficial short-term and long-term outcomes. PMID: 30135417 [PubMed - in process]
Source: Annals of Transplantation - Category: Transplant Surgery Authors: Tags: Ann Transplant Source Type: research
Chronic rejection is the Achilles heel of modern lung transplantation, characterized by a slow, progressive decline in allograft function. Clinically, this manifests as obstructive disease, restrictive disease, or a mixture of the 2 depending on the underlying pathology. The 2 major phenotypes of chronic rejection include bronchiolitis obliterans syndrome and restrictive allograft syndrome. The last decade of research has revealed that each of these phenotypes has a unique underlying pathophysiology which may require a distinct treatment regimen for optimal control. Insights into the intricate alloimmune pathways contribut...
Source: Transplantation - Category: Transplant Surgery Tags: Reviews Source Type: research
More News: Bronchiolitis | Chemistry | Lawsuits | Legislation | Lung Transplant | Medical Law | Toxicology