5-Lipoxygenase as an emerging target against age-related brain disorders

Ageing Res Rev. 2021 May 10:101359. doi: 10.1016/j.arr.2021.101359. Online ahead of print.ABSTRACTNeuroinflammation is a common feature of age-related brain disorders including Alzheimer's disease (AD), Parkinson's disease (PD) and cerebral ischemia. 5-lipoxygenase (5-LOX), a proinflammatory enzyme, modulates inflammation by generating leukotrienes. Abnormal activation of 5-LOX and excessive production of leukotrienes have been detected in the development of age-related brain pathology. In this review, we provide an update on the current understanding of 5-LOX activation and several groups of functionally related inhibitors. In addition, the modulatory roles of 5-LOX in the pathogenesis and progression of the age-related brain disorders have been comprehensively highlighted and discussed. Inhibition of 5-LOX activation may represent a promising therapeutic strategy for AD, PD and cerebral ischemia.PMID:33984528 | DOI:10.1016/j.arr.2021.101359
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Source Type: research