End‐stage renal disease from hemolytic uremic syndrome in the United States, 1995–2010

Abstract Management of hemolytic uremic syndrome (HUS) has evolved rapidly, and optimal treatment strategies are controversial. However, it is unknown whether the burden of end‐stage renal disease (ESRD) from HUS has changed, and outcomes on dialysis in the United States are not well described. We retrospectively examined data for patients initiating maintenance renal replacement therapy (RRT) (n = 1,557,117), 1995–2010, to define standardized incidence ratios (SIRs) and outcomes of ESRD from HUS) (n = 2241). Overall ESRD rates from HUS in 2001–2002 were 0.5 cases/million per year and were higher for patients characterized by age 40–64 years (0.6), ≥65 years (0.7), female sex (0.6), and non‐Hispanic African American race (0.7). Standardized incidence ratios remained unchanged (P ≥ 0.05) between 2001–2002 and 2009–2010 in the overall population. Compared with patients with ESRD from other causes, patients with HUS were more likely to be younger, female, white, and non‐Hispanic. Over 5.4 years of follow‐up, HUS patients differed from matched controls with ESRD from other causes by lower rates of death (8.3 per 100 person‐years in cases vs. 10.4 in controls, P 
Source: Hemodialysis International - Category: Hematology Authors: Tags: Original Article Source Type: research

Related Links:

AbstractPurpose of ReviewWe review the pathophysiology of Shiga-Toxin Enteropathogenic –Hemolytic Uremic Syndrome (STEC-HUS), strategies to ameliorate or prevent evolution of STEC-HUS, management and the improved recognition of long-term adverse outcomes.Recent FindingsFollowing on from the preclinical evidence of a role for the complement system in STEC-HUS, the use of complement blocking agents has been the major focus of most recent clinical research. Novel therapies to prevent or lessen HUS have yet to enter the clinical arena. The long-term outcomes of STEC-HUS, similarly to other causes of AKI, are not as benig...
Source: Current Pediatrics Reports - Category: Pediatrics Source Type: research
The US Centers for Disease Control and the US Food and Drug Administration have declared that the recent nationwide E. Coli outbreak, which contaminated romaine lettuce, ended as of Wednesday. Authorities traced the outbreak back to the Salinas Valley growing region in California. The FDA has lifted a consumer advisory to avoid romaine lettuce from Salinas “as the growing season for this region is over and there is no longer a need for consumers to avoid it.” Health officials had previously advised consumers, retailers and restaurants to throw out any romaine lettuce grown in the Salinas, Calif. region. People...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized onetime public health Source Type: news
(CNN) — Caesar salad lovers rejoice — your crispy romaine lettuce leaves are OK to eat now. The nationwide, monthslong E. coli outbreak linked to romaine lettuce ended Wednesday, according to the US Centers for Disease Control and Prevention and the US Food and Drug Administration. The romaine, which came from Salinas, California, infected a total of 167 people in 27 states. This included 85 hospitalizations, including 15 patients who developed a type of kidney failure — hemolytic uremic syndrome — known to be associated with this particular type of bacteria, E. coli O157:H7. The toxin produced by t...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Syndicated CBSN Boston CNN Romaine Lettuce Source Type: news
This study reported the first case of a four-generation postpartum-aHUS pedigree with isolated CD46 variants and the detailed disease progression, treatment, and prognosis provided more meaningful information for the understanding the disease.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Abstract Shiga toxin-producing Escherichia coli (STEC) are zoonotic pathogens that cause symptoms of severe gastrointestinal disease, including haemolytic uraemic syndrome (HUS), in humans. Currently in England, STEC serotypes other than O157:H7 are not cultured at the local hospital laboratories. The aim of this study was to evaluate the utility of CHROMagar STEC for the direct detection of STEC from faecal specimens in a diagnostic setting, compared to the current reference laboratory method using PCR targeting the Shiga-toxin gene (stx) to test multiple colonies cultured on MacConkey agar. Of the 292 consecutiv...
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research
AbstractDengue disease is an inflammatory driven pathology and complement overactivation is linked to disease severity and vascular leakage. Additionally, dysregulation of complement alternative pathway (AP) components has been described, such as upregulation of complement factor D and downregulation of complement factor H (FH), which activate and inhibit the AP, respectively. Thus, the pathology of severe dengue could in part result from AP dysfunction, even though complement and AP activation usually provide protection against viral infections. In dengue virus ‐infected macrophages and endothelial cells (EC), the site ...
Source: FEBS Letters - Category: Biochemistry Authors: Tags: REVIEW ARTICLE Source Type: research
This study reported the first case of a four-generation postpartum-aHUS pedigree with isolated CD46 variants and the detailed disease progression, treatment, and prognosis provided more meaningful information for the understanding the disease. PMID: 31945341 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - Category: Chemistry Authors: Tags: Clin Chim Acta Source Type: research
ConclusionThe atypical hemolytic uremic syndrome is a rare disease entity requiring a high index of suspicion to diagnose. It is a diagnosis of exclusion. Early diagnosis with prompt treatment will render a better outcome. The atypical hemolytic uremic syndrome needs to be considered in all patients with thrombotic microangiopathy.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Shiga toxin (Stx) produced by enterohemorrhagic E. coli produces hemolytic uremic syndrome and encephalopathies in patients, which can lead to either reversible or permanent neurological abnormalities, or even fatal cases depending on the degree of intoxication. It has been observed that the inflammatory component plays a decisive role in the severity of the disease. Therefore, the objective of this work was to evaluate the behavior of microglial cell primary cultures upon Stx2 exposure and heat shock or lipopolysaccharide challenges, as cues which modulate cellular environments, mimicking fever and inflammation states, re...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Tomoo Kise, Shigeru Fukuyama, Masatsugu UeharaIndian Journal of Nephrology 2020 30(1):35-38 Anti-complement factor H (CFH) autoantibody (Ab)-associated atypical hemolytic uremic syndrome (aHUS) has a poor prognosis in terms of frequent relapses. Although eculizumab is an effective treatment for this type of aHUS, the method of eculizumab discontinuation is not yet established. Herein, we report a case of anti-CFH Ab-associated aHUS in a 6-year-old boy. Eculizumab induction therapy following plasma exchange improved his condition. After 14 months, eculizumab was discontinued because of meningococcal bacteremia. After 6 mon...
Source: Indian Journal of Nephrology - Category: Urology & Nephrology Authors: Source Type: research
More News: Dialysis | Hematology | Hemodialysis | Hemolytic Uremic Syndrome (HUS) | Study | Transplants