AKR1C3 decreased CML sensitivity to Imatinib in bone marrow microenvironment via dysregulation of miR-379-5p

CONCLUSIONS: Altogether, our study identifies a novel signaling regulation of miR-379-5p/AKR1C3/EKR axis in regulating IM resistance in CML cell, and provides a scientific base for exploring AKR1C3 as a biomarker in impeding IM resistance in CML.PMID:33984486 | DOI:10.1016/j.cellsig.2021.110038

Source: Cellular Signalling - May 13, 2021 Category: Cytology Authors: Di Pan Wanwan Yang Yao Zeng Wenjun Li Kaizhen Wang Li Zhao Jia Li Yuting Ye Qinglong Guo Source Type: research