Recent developments in < em > in vitro < /em > and < em > in vivo < /em > models for improved translation of preclinical pharmacokinetic and pharmacodynamics data

Drug Metab Rev. 2021 May 14:1-66. doi: 10.1080/03602532.2021.1922435. Online ahead of print.ABSTRACTImproved PK/PD prediction in early stages of drug development is essential to inform lead optimization strategies and reduce attrition rates. Recently, there have been significant advancements in the development of new in vitro and in vivo strategies to better characterize pharmacokinetic properties and efficacy of drug leads. Herein, we review advances in experimental and mathematical models for clearance predictions, advancements in developing novel tools to capture slowly metabolized drugs, in vivo model developments to capture human etiology for supporting drug development, limitations and gaps in these efforts, and a perspective on the future in the field.PMID:33989099 | DOI:10.1080/03602532.2021.1922435
Source: Drug Metabolism Reviews - Category: Drugs & Pharmacology Authors: Source Type: research