Mechanistic Insights into Cell-free Hemoglobin-induced Injury During Septic Shock

CONCLUSIONS: In the absence and presence of infection, CFH infusions resulted in pulmonary hypertension, cardiogenic shock and multi-organ failure, likely through NO scavenging. In the presence of infection alone, CFH infusions worsened oxygen exchange and lung injury, presumably by supplying iron that promoted bacterial growth. CFH elevation, a known consequence of clinical septic shock, adversely impacts sepsis outcomes through more than one mechanism and is a biologically plausible, non-antibiotic, non-cytokine target for therapeutic intervention.PMID:33989079 | DOI:10.1152/ajpheart.00092.2021
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Source Type: research