Mechanistic Insights into Cell-free Hemoglobin-induced Injury During Septic Shock
CONCLUSIONS: In the absence and presence of infection, CFH infusions resulted in pulmonary hypertension, cardiogenic shock and multi-organ failure, likely through NO scavenging. In the presence of infection alone, CFH infusions worsened oxygen exchange and lung injury, presumably by supplying iron that promoted bacterial growth. CFH elevation, a known consequence of clinical septic shock, adversely impacts sepsis outcomes through more than one mechanism and is a biologically plausible, non-antibiotic, non-cytokine target for therapeutic intervention.PMID:33989079 | DOI:10.1152/ajpheart.00092.2021
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Jeffrey Wang Willard N Applefeld Junfeng Sun Steven B Solomon Jing Feng Zoe G Couse Thomas F Risoleo Robert L Danner Jes ús Tejero Juan Lertora Elmira Alipour Swati Basu Vandana Sachdev Daniel B Kim-Shapiro Mark T Gladwin Harvey G Klein Charles Natanson Source Type: research
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