Direct functionalization of cyclic ethers with maleimide iodides < em > via < /em > free radial-mediated sp < sup > 3 < /sup > C-H activation

Chem Commun (Camb). 2021 May 13;57(39):4787-4790. doi: 10.1039/d1cc01484f.ABSTRACTCyclic ethers are important scaffolds employed in the synthesis of various natural products and pharmaceutical ingredients. A novel free radical-initiated reaction between cyclic ethers and maleimide iodides through C-H activation is developed, avoiding the use of transition metallic catalysts. This method provides a simple approach to derive cyclic ethers, which were further applied in various cross coupling reactions.PMID:33982730 | DOI:10.1039/d1cc01484f

Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Xiaoyu Cheng Baojun Li Mengsi Zhang Haotian Lu Wenbo Wang Yun Ding Aiguo Hu Source Type: research