Late-stage ligand functionalization < em > via < /em > the Staudinger reaction using phosphine-appended 2,2'-bipyridine

Chem Commun (Camb). 2021 May 13. doi: 10.1039/d1cc01407b. Online ahead of print.ABSTRACTThe ability of a phosphine-appended-2,2'-bipyridine ligand ((Ph2P)2bpy) to serve as a platform for late-stage ligand modifications was evaluated using tetrahedral (Ph2P)2bpyFeCl2. We employed a post-metalation Staudinger reaction to install a series of functionalized arenes, including those containing Brønsted and Lewis acidic groups. This reaction sequence represents a versatile strategy to both tune the ligand donor properties as well as directly incorporate appended functionality.PMID:33982731 | DOI:10.1039/d1cc01407b

Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Deeb Taher Jessica R Wilson Grayson Ritch Matthias Zeller Nathaniel K Szymczak Source Type: research