Visualization of intra-tumor pharmacokinetics of [fam-] trastuzumab deruxtecan (DS-8201a) in HER2 heterogeneous model using phosphor-integrated dots imaging analysis

CONCLUSIONS: Our results suggest that T-DXd is distributed to tumor tissues via trastuzumab in a HER2-dependent manner and then to adjacent HER2-negative areas. We successfully visualized the intra-tumor distribution of T-DXd and its mechanism of action, the so-called "bystander effect".PMID:33980613 | DOI:10.1158/1078-0432.CCR-21-0397

Source: Clinical Genitourinary Cancer - May 13, 2021 Category: Cancer & Oncology Authors: Mikiko Suzuki Shigehiro Yagishita Kiyoshi Sugihara Yusuke Ogitani Tadaaki Nishikawa Mayu Ohuchi Takashi Teishikata Takahiro Jikoh Yasushi Yatabe Kan Yonemori Kenji Tamura Kosei Hasegawa Akinobu Hamada Source Type: research