Genetic variants in < em > LGALS3 < /em > are related to lower galectin-3 serum levels and clinical outcomes in systemic sclerosis patients: A case-control study

CONCLUSION: The LGALS3 rs4652 A/C was more frequent in SSc patients and related to lower Gal-3 levels. These findings were corroborated through a GLM to estimate Gal-3 values. Also, by model equations, Gal-3 levels may be predicted by HAQ, SHAQ, PAH, myopathy, and LGALS3 rs4652 and rs2075601 factors. In these ways, we suggest that galectins may be promising biomarkers to identify susceptibility to SSc as well as to identify HAQ, SHAQ, PAH, and myopathy outcomes.PMID:33973825 | DOI:10.1080/08916934.2021.1919881

Source: Autoimmunity - May 11, 2021 Category: Allergy & Immunology Authors: Eudes Gustavo Constantino Cunha Camilla Albertina Dantas de Lima Kamila de Melo Vilar Marcelo Francisco de N óbrega Anderson Rodrigues de Almeida Michelly Cristiny Pereira Andr éa Tavares Dantas Rafaela Silva Guimar ães Gonçalves Moacyr Jesus Barreto Source Type: research