Synthesis of 2-isoxazolyl-2,3-dihydrobenzofurans < em > via < /em > palladium-catalyzed cascade cyclization of alkenyl ethers

Chem Commun (Camb). 2021 May 13;57(39):4799-4802. doi: 10.1039/d1cc00709b.ABSTRACTA novel palladium-catalyzed cascade cyclization reaction of alkenyl ethers with alkynyl oxime ethers for the construction of poly-heterocyclic scaffolds has been developed, in which the electron-rich alkene moiety functions as a three-atom unit, simultaneously dealing well with the coordination and regioselectivity of electron-rich olefins under metal catalysis. The strategy features excellent regio- and chemoselectivities as well as good functional group tolerance. Moreover, the newly formed 2-isoxazolyl-2,3-dihydrobenzofuran products can be further transformed to diverse complex heterocycles, demonstrating their potential applications in organic synthesis and medicinal chemistry.PMID:33982707 | DOI:10.1039/d1cc00709b

Source: Chemical Communications - May 13, 2021 Category: Chemistry Authors: Fei Zhou Can Li Meng Li Yangbin Jin Huanfeng Jiang Yingjun Zhang Wanqing Wu Source Type: research