Cultured human uveal melanocytes express/secrete CXCL1 and CXCL2 constitutively and increased by lipopolysaccharide via activation of Toll-like receptor 4

CONCLUSIONS: : This is the first report on the LPS-induced expression of CXCL1 and CXCL2 by uveal melanocytes via the activation of TLR4. These results suggest that uveal melanocytes may play a role in the immune reaction that eliminates the invading pathogens. Conversely, an excessive LPS-induced inflammatory reaction may also lead to the development of inflammatory ocular disorders, such as non-infectious uveitis.PMID:33979551 | DOI:10.1080/02713683.2021.1929326

Source: Current Eye Research - May 12, 2021 Category: Opthalmology Authors: Dan-Ning Hu Ruihua Zhang Shen Yao Codrin E Iacob Wei-En Yang Richard B Rosen Shun-Fa Yang Source Type: research