Uganda: Malaria Mortality Upsurge Worries Gulu Authorities

[Monitor] Malaria has been the leading cause of death in Gulu District in the past one year, a report has revealed .
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news

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[Capital FM] Nairobi -- The Ministry of Health has called for enhanced uptake of the newly rolled out RTS, S/AS01 vaccine to bolster efforts to combat malaria among children.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
[VOA] Abuja -- The World Health Organization's endorsement of the world's first malaria vaccine marks a major advance against the mosquito-borne illness, which kills some 265,000 children in Africa annually.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Trends Parasitol. 2021 Oct 11:S1471-4922(21)00233-6. doi: 10.1016/j.pt.2021.09.008. Online ahead of print.ABSTRACTPlasmodium and other vector-borne pathogens have evolved mechanisms to hijack the mammalian fibrinolytic system to facilitate infection of the human host and the invertebrate vector. Plasmin, the effector protease of fibrinolysis, maintains homeostasis in the blood vasculature by degrading the fibrin that forms blood clots. Plasmin also degrades proteins from extracellular matrices, the complement system, and immunoglobulins. Here, we review some of the mechanisms by which vector-borne pathogens interact with c...
Source: Trends in Parasitology - Category: Parasitology Authors: Source Type: research
Mol Aspects Med. 2021 Oct 11:101028. doi: 10.1016/j.mam.2021.101028. Online ahead of print.ABSTRACTThalassemias (α, β, γ, δ, δβ, and εγδβ) are the most common genetic disorders worldwide and constitute a heterogeneous group of hereditary diseases characterized by the deficient synthesis of one or more hemoglobin (Hb) chain(s). This leads to the accumulation of unstable non-thalassemic Hb chains, which precipitate and cause intramedullary destruction of erythroid precursors and premature lysis of red blood cells (RBC) in the peripheral blood. Non-thalassemic Hbs dis...
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
[The Conversation Africa] Globally more than 400,000 people die of malaria annually. Africa carries a disproportionate burden of the disease. In 2019, 94% of deaths and cases were recorded in the region.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
[Nation] A top Kenyan scientist who participated in a ground-breaking medical research is confident of a malaria-free future after the World Health Organization (WHO) approved the first vaccine for children.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
Mitochondria are vital organelles of eukaryotic cells, participating in key metabolic pathways such as cellular respiration, thermogenesis, maintenance of cellular redox potential, calcium homeostasis, cell signaling, and cell death. The phylum Apicomplexa is entirely composed of obligate intracellular parasites, causing a plethora of severe diseases in humans, wild and domestic animals. These pathogens include the causative agents of malaria, cryptosporidiosis, neosporosis, East Coast fever and toxoplasmosis, among others. The mitochondria in Apicomplexa has been put forward as a promising source of undiscovered drug targ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
d B. Sattelle Mosquito-borne viruses including dengue, Zika, and Chikungunya viruses, and parasites such as malaria and Onchocerca volvulus endanger health and economic security around the globe, and emerging mosquito-borne pathogens have pandemic potential. However, the rapid spread of insecticide resistance threatens our ability to control mosquito vectors. Larvae of Aedes aegypti were screened with the Medicines for Malaria Venture Pandemic Response Box, an open-source compound library, using INVAPP, an invertebrate automated phenotyping platform suited to high-throughput chemical screening of larval motility. We id...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Last week the World Health Organization approved the world ’s first malaria vaccine. It’s been hailed as a historic breakthrough that could save tens of thousands of lives each year. But researchers have been trying to create one for more than a century – so why has it taken so long? Anand Jagatia speaks to Dr Latif Ndeketa and Prof Chris Drakeley abo ut how the new RTS,S vaccine works and why it’s been so difficult to produceArchive: WHO, ITV NewsContinue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Science Malaria Vaccines and immunisation Health World news Source Type: news
Was it a tick-borne parasite — or something weirder?
Source: NYT Health - Category: Consumer Health News Authors: Tags: Malaria Medicine and Health Source Type: news
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