Vagotomy and Splenectomy Reduce Insulin Secretion and Interleukin-1β

Conclusions The absence of the spleen attenuated or blocked the effects of VAG on adiposity, triglycerides and glucose homeostasis, suggesting a synergistic effect of both on metabolism. The vagus nerve and spleen modulate the presence of interleukin-1β in β cells, possibly because of the reduction of glucose-induced insulin secretion, indicating a bidirectional flow between autonomous neural firing and the spleen, with repercussions for the endocrine pancreas.
Source: Pancreas - Category: Gastroenterology Tags: Original Articles Source Type: research