ATP6V0d2 Suppresses Alveoli Macrophage Alternative Polarization and Allergic Asthma via Degradation of PU.1

CONCLUSIONS: Our results identify macrophage Atp6v0d2, as an induced feedback inhibitor of asthma disease severity by promoting Pu.1 lysosomal degradation, which may in turn leads to reduced AAM polarization and Ccl17 production.PMID:33733641 | PMC:PMC7984956 | DOI:10.4168/aair.2021.13.3.479

Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Na Liu Yuchen Feng Huicheng Liu Wenliang Wu Yuxia Liang Pingfei Li Zhengping Wei Min Wu Zhao Hui Tang Junyan Han Xiang Cheng Zheng Liu Arian Laurence Huabin Li Guohua Zhen Xiang Ping Yang Source Type: research