The Effects of Aerobic Exercise in Patients with Early-Onset Dementia: A Scoping Review
Dement Geriatr Cogn Disord. 2021 May 6:1-8. doi: 10.1159/000516231. Online ahead of print.ABSTRACTBACKGROUND: Early-onset dementia (EOD) defines all dementia related conditions with an onset before the age of 65 years. EOD places a large and distressing psychological, emotional and financial burden on the individuals themselves and their caregivers. For various reasons, diagnostic and treatment strategies for EOD are very challenging. There is a general agreement that not only the human body but also the mind benefits from physical activity and/or exercise. Especially aerobic exercise has shown to have favorable effects on cognitive functions in healthy older adults, as well as in patients with MCI and dementia. However, there are major differences in age, physical fitness level and clinical presentation between EOD and late-onset dementia. Therefore, one cannot just assume that the same type and intensity of exercise will lead to similar effects in the former population. By conducting this scoping review, the authors aimed to identify the evidence on the effectiveness of aerobic exercise on physical and mental health outcomes in individuals with EOD, display gaps in this context, and formulate related directions for future research.SUMMARY: There are a number of reasons to assume that aerobic exercise might be extremely valuable within individuals with EOD. However, this scoping review led to the surprising and striking finding that not a single study so far has investigated...
DEMENTIA can be tricky to pick up on in the earliest stages. However, mounting research indicates a certain time of day when symptoms may be more noticeable. What time do you need to be on full alert?
CONCLUSIONS: Individually customized, multicomponent exercise programs lead to improved levels of cognitive function, depression, and quality of life, especially among those who are more frail. PMID: 33029968 [PubMed]
Conclusion: SLT induces relaxation of rat isolated tail artery through endothelium-independent mechanisms. The SLT-induced vasodilatation appeared to be jointly meditated by blockages of extracellular Ca2+ influx via receptor-gated and voltage-gated Ca2+ channels and inhibition of the release of Ca2+ from the sarcoplasmic reticulum. PMID: 33029174 [PubMed]
In conclusion, in this database study of elderly patients coded with NAFLD no independent association with incident dementia was detected. Risk assessment regarding dementia in patients with NAFLD should be carried out in the same way as for metabolic burdened patients.
Publication date: Available online 8 October 2020Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): H.J. Jung, J.Y. Lee, Y.-S. Choi, H.G. Choi, J.H. Wee
FRIDAY, Oct. 9, 2020 -- Patients with type 2 diabetes (T2D) are more likely to develop vascular dementia and nonvascular dementia compared with controls without diabetes, according to a study presented at the annual meeting of the European...
CONCLUSIONS: Findings provide a novel understanding of ARND prevalence in a previously understudied area, although the prevalence estimate is conservative and should be interpreted cautiously for reasons discussed. Findings also highlight an inconsistency between diagnoses presented in nosological systems (e.g., International Classification of Diseases-10th Revision) and those used in practice and therefore a need to evaluate novel diagnostic conceptualizations of alcohol-related neurocognitive impairment. PMID: 33028471 [PubMed - in process]
Dementia risk did not differ by general, regional anesthesia in seniors undergoing elective surgery
This report summarizes the discussion and recommendations from a working group convened by the National Heart, Lung, and Blood Institute and the National Institute of Neurological Disorders and Stroke to evaluate the state of the field in VCID research, identify research priorities, and foster collaborations. As discussed in this report, advances in understanding the biological mechanisms of VCID across the wide spectrum of pathologies, chronic systemic comorbidities, and other risk factors may lead to potential prevention and new treatment strategies to decrease the burden of dementia. Better understanding of the social d...
Conditions: Pain; Opioid Use; Dementia; Unconscious; Ventilator Lung Intervention: Device: PMD200 Sponsor: Medasense Biometrics Ltd Not yet recruiting