Cancers, Vol. 13, Pages 2344: Photosensitizing Medications and Skin Cancer: A Comprehensive Review

Cancers, Vol. 13, Pages 2344: Photosensitizing Medications and Skin Cancer: A Comprehensive Review Cancers doi: 10.3390/cancers13102344 Authors: Elisabeth A. George Navya Baranwal Jae H. Kang Abrar A. Qureshi Aaron M. Drucker Eunyoung Cho (1) The incidence of skin cancer is increasing in the United States (US) despite scientific advances in our understanding of skin cancer risk factors and treatments. In vitro and in vivo studies have provided evidence that suggests that certain photosensitizing medications (PSMs) increase skin cancer risk. This review summarizes current epidemiological evidence on the association between common PSMs and skin cancer. (2) A comprehensive literature search was conducted to identify meta-analyses, observational studies and clinical trials that report on skin cancer events in PSM users. The associated risks of keratinocyte carcinoma (squamous cell carcinoma and basal cell carcinoma) and melanoma are summarized, for each PSM. (3) There are extensive reports on antihypertensives and statins relative to other PSMs, with positive and null findings, respectively. Fewer studies have explored amiodarone, metformin, antimicrobials and vemurafenib. No studies report on the individual skin cancer risks in glyburide, naproxen, piroxicam, chlorpromazine, thioridazine and nalidixic acid users. (4) The research gaps in understanding the relationship between PSMs and skin cancer outlined in this review should be prioritized because the US popu...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research