The prevalence and role of functional autoantibodies to angiotensin-converting-enzyme-2 in patients with systemic sclerosis

CONCLUSIONS: Anti-ACE2 antibodies appear to be other functional autoantibodies with the potential to dysregulate the balance between Ang II and Ang-(1-7). They are non-specific for SSc and probably result from polyautoimmunity which affect some of SSc patients. Their occurrence in SSc settings may be associated with a severe depletion of plasma Ang-(1-7).PMID:33910447 | DOI:10.1080/08916934.2021.1916915

Source: Autoimmunity - April 29, 2021 Category: Allergy & Immunology Authors: Bartosz Mizio łek Marcin Sie ńczyk Renata Grzywa Agnieszka Łupicka-Słowik Eugeniusz Kucharz Przemys ław Kotyla Beata Bergler-Czop Source Type: research