Perturbed Microbiota/Immune Homeostasis in Multiple Sclerosis

Conclusions
Gut and systemic microbiota/immune homeostasis are perturbed in MS. Our results argue that defective IgA responses in MS are linked to a breakdown of systemic tolerance to gut microbiota leading to an enhanced triggering of systemic IgG immunity against gut commensals occurring early in MS.

Source: Neurology Neuroimmunology and Neuroinflammation - May 11, 2021 Category: Neurology Authors: Sterlin, D., Larsen, M., Fadlallah, J., Parizot, C., Vignes, M., Autaa, G., Dorgham, K., Juste, C., Lepage, P., Aboab, J., Vicart, S., Maillart, E., Gout, O., Lubetzki, C., Deschamps, R., Papeix, C., Gorochov, G. Tags: All Immunology, Autoimmune diseases, Multiple sclerosis Article Source Type: research