Infliximab modifies regulatory T cells and co-inhibitory receptor expression on circulating T cells in psoriasis

CONCLUSION: Anti-TNF-α therapy increased the frequency of Tregs and TIGIT, LAG-3, CTLA-4 expression but reduced PROCR expression on circulating CD4+ T cells in psoriasis patients. The baseline proportion of Tregs and the expression level of TIGIT on circulating CD4+ T cells might serve as predictive markers for the degree of disease remission benefited from infliximab treatment.PMID:33965878 | DOI:10.1016/j.intimp.2021.107722

Source: International Immunopharmacology - May 9, 2021 Category: Allergy & Immunology Authors: Yingyuan Yu Zeyu Chen Yu Wang Ying Li Jiajing Lu Lian Cui Zengyang Yu Yangfeng Ding Chunyuan Guo Xilin Zhang Yuling Shi Source Type: research