Chlorogenic acid is a positive regulator of MDA5, TLR7 and NF- κB signaling pathways mediated antiviral responses against Gammacoronavirus infection

In conclusion, these results showed that at high concentration CGA is a strong anti-IBV compound that can effectively regulate the innate immunity through MDA5, TLR7 and NF-κB signaling pathways and have the potential to induce the cell mediated and humoral immune response in IBV infected chickens.PMID:33971495 | DOI:10.1016/j.intimp.2021.107671

Source: International Immunopharmacology - May 10, 2021 Category: Allergy & Immunology Authors: Muhammad Abaidullah Shuwei Peng Xu Song Yuanfeng Zou Lixia Li Renyong Jia Zhongqiong Yin Source Type: research