Pathological axis fracture secondary to a solitary bone plasmacytoma: Two cases and a literature review

CONCLUSION: Although rare, unstable SBP may present atypical cervical location that readily responds to surgical descompression/fusion and radiotherapy.PMID:33948335 | PMC:PMC8088476 | DOI:10.25259/SNI_253_2021
Source: Surgical Neurology International - Category: Neurosurgery Authors: Source Type: research

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Suyash Singh, Ashutosh Kumar, Kamlesh Singh Bhaisora, Arun Kumar Srivastava, Sanjay BehariJournal of Craniovertebral Junction and Spine 2019 10(3):192-196 Localized proliferation of atypical plasma cells, either at bony or extramedullary, forms a rare subset of multiple myeloma (MM) disorders. The patients usually present with intractable pain and pathological fractures and respond well to radiotherapy. The clinical presentation is variable and radiologically is nonspecific. The spinal location is rare, and the solitary plasmacytoma in the intradural extramedullary (IDEM) region is unusual. Herein, we report the second ca...
Source: Journal of Craniovertebral Junction and Spine - Category: Orthopaedics Authors: Source Type: research
CONCLUSIONWhen detecting a lytic spinal tumor in a patient who suffers from LS a SPB should be taken under consideration.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
We examined factors associated with upfront RT in a multivariable logistic model. We then examined the association between upfront RT and overall survival (OS) in a proportional hazard model adjusting for age, sex, race, income, insurance status, comorbidity index, year of diagnosis, type of treating hospital, and time from diagnosis to start of therapy.ResultsOf the 88,995 patients with myeloma, 15,223 (18%) received upfront RT, at median 15 days from diagnosis. Median radiation dose was 3000 cGy delivered over median 10 fractions, with the most common targets being spine/skull (59%), hips/pelvis (12%), and other bones (1...
Source: Blood - Category: Hematology Authors: Tags: 653. Myeloma: Therapy, excluding Transplantation: Poster II Source Type: research
In this report, we present a 53-year-old woman with primary mast cell sarcoma of the thoracic spine vertebrae. Mast cell sarcoma is an aggressive and rare cancer. To date, no cases of primary mast cell sarcoma have been reported in the spinal vertebrae. The patient initially presented with a 1-month history of pelvic and abdominal pain. Inconclusive gynecological evaluation resulted in a CT of the abdomen and pelvis, demonstrating a destructive lesion centered at the 11th thoracic vertebral body. The patient underwent a two-stage spine operation for T11 corpectomy and T7-L3 posterior spinal fusion. Histopathological, immun...
Source: Clinical Neuropathology - Category: Pathology Authors: Tags: Clin Neuropathol Source Type: research
CONCLUSIONS: Solitary plasmacytomas of the vertebral bodies are difficult lesions to treat secondary to their location and risk of neurologic compromise. Surgical intervention with tumor resection and adjuvant chemotherapy or radiation is the recommended treatment option. PMID: 28868185 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
A review of 92 cases of multiple myeloma (66 males and 26 females) seen at the King Faisal Specialist Hospital and Research Centre from October 1975 through December 1987 revealed the age for affected patients ranged from 23 to 90 years (mean, 56 years). Six percent of the patients were less than 40 years old at the time of diagnosis. Bone pain was the most common presenting symptom in our patients (80%), most frequently involving the back. Anemia was the initial finding in 74%, followed by plasmacytoma (22.8%), hypercalcemia (19.6%), and renal insufficicency (18.5%). Skeletal survey abnormalities were seen in 92.4% of the...
Source: Annals of Saudi Medicine - Category: Journals (General) Tags: ISSUE 6 Source Type: research
Case history A 55-year-old male patient presented with backache for 1 month. There was no history of trauma. Haematological evaluation revealed an elevated erythrocyte sedimentation rate. Radiographic examination showed partial collapse of D12 vertebra with suspicious lytic lesion. MRI showed well-defined lytic lesion in D12 vertebral body appearing mildly hypointense on T1-weighted (T1W) images and mildly hyperintense on T2-weighted (T2W) images, with associated radially arranged thickened cortical struts appearing hypointense on T1W/T2W images, mimicking cortical sulci in brain (figure 1). A similar imaging appearan...
Source: Postgraduate Medical Journal - Category: Journals (General) Authors: Tags: Journalology, Pain (neurology), Breast cancer, Screening (oncology), Radiology, Surgical diagnostic tests, General surgery, Radiology (diagnostics), Ethics Images in medicine Source Type: research
Myeloma bone disease (MBD), the skeletal lesions caused by multiple myeloma, is also known as skeletal related events and includes bone pain, osteoporosis, pathological fractures, osteolytic bone lesions, spinal instability, spinal cord and nerve root compression and extramedullary plasmacytoma. It is now generally accepted that patients with these complications usually require surgical management and that such treatment is safe and effective. The aims of surgical interventions are to alleviate pain, improve quality of life, treat potential or existing pathological fractures, decompress the spinal cord and nerve roots, and...
Source: Orthopaedic Surgery - Category: Orthopaedics Tags: CONSENSUS Source Type: research
​​BY SEFAKO PHALA; ​ROBERT STATZ; ANDREW VICTOR; MOHAMMED HASSAN-ALI, MD, MSC; &AHMED RAZIUDDIN, MDA 65-year-old Caucasian man was brought to the ED via ambulance complaining of worsening upper back pain for one week. His primary care physician had recently prescribed him NSAIDs and muscle relaxants, which failed to provide relief. The newest symptoms were numbness and weakness over his left arm and leg. The patient reported no history of trauma to his back nor did he have any chronic illnesses. Physical exam showed paresthesia in the left upper extremity in a dermatomal distribution pattern that suggested f...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
A 31-year-old man was admitted to our hospital with back pain for three months. His medical and family history was unremarkable. Physical examination revealed tenderness to palpation of the thoracic spine. Radiographs of the thoracic spine showed height loss of T5 vertebral body. Computerized tomography (CT) and magnetic resonance imaging (MRI) was performed. CT showed expansile lytic lesion with thinned cortex (Fig 1). The lesion was low signal intensity on T1-weighted MR images and high signal intensity on the T2-weighted MR images (Fig 2).
Source: The Spine Journal - Category: Orthopaedics Authors: Tags: Images of Spine Care Source Type: research
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