Cetylpyridinium chloride (CPC) and Miramistin (MST) as antiseptic substances in chronic wound management - prospects and limitations.

Cetylpyridinium chloride (CPC) and Miramistin (MST) as antiseptic substances in chronic wound management - prospects and limitations. J Med Microbiol. 2015 Feb 13; Authors: Fromm-Dornieden C, Rembe JD, Schäfer N, Böhm J, Stuermer EK Abstract The antimicrobial activity of Cetylpyridinium chloride (CPC) and Miramistin (MST) solutions in different concentrations (5 x 10-5 to 0.4%) and a fleece, containing 0.15% CPC, were tested against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli after 30 minutes (solutions) and 60 minutes (fleece) of incubation, respectively. Furthermore, cytotoxic effects of CPC and MST were examined in human keratinocyte (HaCaT) and murine fibroblast (L929) cell lines. A dose of 3 x 10-3% CPC or MST was sufficient to entirely eradicate S. aureus after 30 minutes of incubation. To achieve the same effect higher concentrations against E. coli (0.025% CPC; 0.0125% MST) and P. aeruginosa (0.5% CPC; 0.05% MST) were required. The CPC-fleece showed a high antiseptic effect against all three bacterial strains, though it did not completely eliminate P. aeruginosa. Both substances showed a high cytotoxic impact in higher tested concentrations (CPC: > 3 x 10-3% MST > 8 x 10-4%). CPC showed high antimicrobial potency in low concentrations against S. aureus, accompanied by low cytotoxic (side) effects in these concentrations, while the required minimal concentration to eradicate E. coli and P. aerugi...
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research