Cognitive outcome in children with infantile spasms using a standardized treatment protocol. A five-year longitudinal study

Infantile spasms (IS) is the most common severe infantile epilepsy, characterized by clinical spasms and hypsarrhythmia on electroencephalography (although spasms can also be diagnosed without typical EEG findings). The prognosis for most patients with IS is poor and may include evolution to Lennox Gastaut Syndrome and other drug-resistant epilepsies, severe intellectual disability, and other neurodevelopmental impairments such as autism spectrum disorders [1-3]. Intellectual disability, often in the moderate to severe range, affects up to 70-90% of patients [2, 4, 5].

Source: Seizure: European Journal of Epilepsy - May 11, 2021 Category: Neurology Authors: Jonathan Y. Bitton, B éatrice Desnous, Hannelore C. Sauerwein, Mary Connolly, Shelly K. Weiss, Elizabeth J. Donner, Sharon Whiting, Ismail S. Mohamed, Elaine C. Wirrell, Gabriel M. Ronen, Anne Lortie, for the CPEN Source Type: research