Hemodialysis in acute methanol poisoning: is there really good evidence?

3.5 out of 5 stars Recommendations for the Role of Extracorporeal Treatments in the Management of Acute Methanol Poisoning: A Systematic Review and Consensus Statement. Roberts DM et al. Crit Care Med 2015 Feb;43:461-472. Abstract The Extracorporeal Treatment in Poisoning (EXTRIP) Workgroup was established to provide evidence-based guidance on the use of hemodialysis and other methods of extracorporeal treatment in various toxic exposures. The workgroup has published previous papers giving their recommendations regarding poisoning by acetaminophen, lithium, carbamazepine, barbiturate, tricyclic antidepressants, and thallium. This is a tremendously ambitious project, involving experts from many fields of medicine and pharmacology, and extensive review of the literature. Unfortunately, for many of these intoxications, good evidence simply does not exist. In this instance, all of the major  recommendations regarding methanol are rated as 1D. The rating of “1” indicates a “strong recommendation.” A level of evidence rated “D” is described in the paper thusly: “very low level of evidence (our estimate of the effect is just a guess, and it is very likely that the true effect is substantially different from our estimate of the effect.)” That last statement is refreshingly honest. I’ve disagreed with some members of the workgroup in the past about this, but I still believe you can’t make real evidence-based recommendation...
Source: The Poison Review - Category: Toxicology Authors: Tags: Medical evidence-based recommendations extracorporeal treatment extrip hemodialysis methanol toxic alcohol Source Type: news