Pericyte-specific deletion of Ninjurin-1 induces fragile vasa vasorum formation and enhances intimal hyperplasia of injured vasculature

In conclusion, deletion of Ninj1 in pericytes induces the immature vasa vasorum formation of injured vasculature and exacerbates adventitial inflammation and intimal hyperplasia. Thus, Ninj1 contributes to the vasa vasorum maturation in response to vascular injury, and to reduction of vascular remodeling.PMID:33961504 | DOI:10.1152/ajpheart.00931.2020

Source: American Journal of Physiology. Heart and Circulatory Physiology - May 7, 2021 Category: Physiology Authors: Kiwamu Horiuchi Kohei Kano Akiho Minoshima Taiki Hayasaka Atsushi Yamauchi Takamitsu Tatsukawa Risa Matsuo Yuri Yoshida Yui Tomita Maki Kabara Naoki Nakagawa Naofumi Takehara Naoyuki Hasebe Jun-Ichi Kawabe Source Type: research