A nearly-neutral biallelic Moran model with biased mutation and linear and quadratic selection

Theor Popul Biol. 2021 May 5:S0040-5809(21)00028-9. doi: 10.1016/j.tpb.2021.03.003. Online ahead of print.ABSTRACTIn this article, a biallelic reversible mutation model with linear and quadratic selection is analyzed. The approach reconnects to one proposed by Kimura (1979), who starts from a diffusion model and derives its equilibrium distribution up to a constant. We use a boundary-mutation Moran model, which approximates a general mutation model for small effective mutation rates, and derive its equilibrium distribution for polymorphic and monomorphic variants in small to moderately sized populations. Using this model, we show that biased mutation rates and linear selection alone can cause patterns of polymorphism within and substitution rates between populations that are usually ascribed to balancing or overdominant selection. We illustrate this using a data set of short introns and fourfold degenerate sites from Drosophila simulans and Drosophila melanogaster.PMID:33964284 | DOI:10.1016/j.tpb.2021.03.003

Source: Theoretical Population Biology - May 8, 2021 Category: Biology Authors: Claus Vogl Lynette Caitlin Mikula Source Type: research