Detecting Borrelia Spirochetes: A Case Study With Validation Among Autopsy Specimens

In this report, we describe the use of multiple molecular detection techniques for this pathogen and its application to a case study of a Lyme disease patient. The patient had a history of Lyme disease, was treated with antibiotics, and years later developed chronic symptoms including dementia. The patient's pathology and clinical case description was consistent with Lewy body dementia. B. burgdorferi was identified by PCR in several CNS tissues and by immunofluorescent staining in the spinal cord. These studies offer proof of the principle that persistent infection with the Lyme disease spirochete may have lingering consequences on the CNS.
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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Source: Journal of Neurology - Category: Neurology Source Type: research
Elevated blood markers for neurodegeneration can better predict risk of dementia when markers for cerebrovascular disease are also elevated. A link between vascular health and mental health has been found.First Look
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Neurology & Neurosurgery News Source Type: news
Conditions:   Alzheimer Disease;   Dementia;   Brain Diseases;   Central Nervous System Diseases;   Nervous System Diseases;   Tauopathies;   Neurodegenerative Diseases;   Neurocognitive Disorders;   Mental Disorders Intervention:   Behavioral: Harmony at HOME (H@H) Sponsor:   Allison Gibson Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Ernest Hemingway is widely regarded as one of the greatest fiction writers of all time. During his life, he demonstrated several signs of psychological suffering with gradual worsening and presentation of cognitive issues over his late years. Some of his s...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news
Conclusions: We found that many studies investigated cognitive function, behavioral and psychological symptoms of dementia (BPSD), and quality of life; compared to BPSD, various types of rating scales were used for cognitive function. By standardizing the rating scales, we can contribute to the accumulation of evidence for music therapy for dementia.Dement Geriatr Cogn Disord Extra 2022;12:6 –13
Source: Dementia and Geriatric Cognitive Disorders Extra - Category: Geriatrics Source Type: research
This study aimed to verify if applying machine-learning analysis to spectral indices of the arterial pulse waveform can be used to discriminate different cognitive conditions of community subjects. 3-min Radial arterial blood pressure waveform (BPW) signals were measured noninvasively in 123 subjects. Eight machine-learning algorithms were used to evaluate the following 4 pulse indices for 10 harmonics (total 40 BPW spectral indices): amplitude proportion and its coefficient of variation; phase angle and its standard deviation. Significant differences were noted in the spectral pulse indices between Alzheimer’s-d...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
Cell Mol Neurobiol. 2021 Oct 18. doi: 10.1007/s10571-021-01154-8. Online ahead of print.ABSTRACTAlzheimer's disease (AD), the most frequently diagnosed dementia, is a senile neurodegenerative disorder characterized by amnesia and cognitive dysfunction. Unfortunately, there are still no successful strategies to prevent AD progression. Thus, the vast majority of research focuses on recognizing risk factors for developing and progressing this disease. Human spirochetes, fungi, Borrelia burgdorferi, Chlamydophila pneumoniae, Helicobacter pylori, and human herpes simplex virus type 1 (HSV-1) have all been implicated in the deve...
Source: Cellular and Molecular Neurobiology - Category: Cytology Authors: Source Type: research
Growing up a musically-obsessed child in the 80's, Daryl Hall was one of my biggest inspirations. A masterful, inventive songwriter with an ocean of soul, he set me on the path to being an artist, to never waste a word, and to sing because I mean it. With six number ones and five additional top ten hits throughout the 70's and 80's Daryl Hall and John Oates are the number one duo in music history. Still at the top of his game at 69 years old, Daryl has won legions of new fans with his hit MTV Live show Live From Daryl's House. In February of 2015, at my very sickest from chronic Lyme and Bartonella, after it was missed b...
Source: Science - The Huffington Post - Category: Science Source Type: news
We report a patient with features of atypical dementia and normal pressure hydrocephalus (NPH), who improved dramatically after a single 3-week course of ceftriaxone.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research
Tara and David Geraghty On Dec. 22, three days before Christmas, 55-year-old David A. Geraghty died from complications of a supposedly rarely fatal infection: Lyme disease. As reported in The Valley Breeze, a Lincoln, R.I. newspaper, Geraghty and his family found out conclusively that he has had Lyme disease just one year ago, last December. As was the case for me and is not uncommon in other cases of Lyme disease diagnoses, it was Geraghty and his wife -- not his physicians -- who pushed for investigation into the cause of his illness and ultimately were responsible for discovering that Lyme disease was at the root. Gerag...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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