Detecting Borrelia Spirochetes: A Case Study With Validation Among Autopsy Specimens

In this report, we describe the use of multiple molecular detection techniques for this pathogen and its application to a case study of a Lyme disease patient. The patient had a history of Lyme disease, was treated with antibiotics, and years later developed chronic symptoms including dementia. The patient's pathology and clinical case description was consistent with Lewy body dementia. B. burgdorferi was identified by PCR in several CNS tissues and by immunofluorescent staining in the spinal cord. These studies offer proof of the principle that persistent infection with the Lyme disease spirochete may have lingering consequences on the CNS.
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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Conditions:   Dementia;   Dementia, Vascular;   Dementia With Lewy Bodies;   Dementia of Alzheimer Type;   Dementia Frontal;   Dementia, Mixed Intervention:   Other: Observational Sponsor:   Gulhane Training and Research Hospital Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
JOE KINNEAR, 74, is battling "late stage" dementia, the former football manager's family have revealed today. The announcement has been made in a bid to draw attention to a vital link between football and brain decline.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
The shrinkage is linked to developing Alzheimer's disease or another type of dementia.
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Dementia Source Type: blogs
Aging (Albany NY). 2021 Sep 22;13(undefined). doi: 10.18632/aging.203557. Online ahead of print.ABSTRACTINTRODUCTION: Cerebral small vessel disease (SVD) is prevalent in the elderly population and is associated with increased risk of dementia, stroke and disability. Currently there are no clear targets or strategies for the treatment of cerebral SVD. We set out to identify modifiable vascular treatment targets.PATIENTS AND METHODS: 112 participants with and without a history of CVD underwent macrovascular, microvascular and endothelial function tests and an MRI head scan.RESULTS: Increased carotid intima media thickness an...
Source: Aging - Category: Biomedical Science Authors: Source Type: research
CNS Neurosci Ther. 2021 Sep 22. doi: 10.1111/cns.13730. Online ahead of print.ABSTRACTAIM: The role of vascular dementia (VaD)-associated genes in Alzheimer's disease (AD) remains elusive despite similar clinical and pathological features. We aimed to explore the relationship between these genes and AD in the Chinese population.METHODS: Eight VaD-associated genes were screened by a targeted sequencing panel in a sample of 3604 individuals comprising 1192 AD patients and 2412 cognitively normal controls. Variants were categorized into common variants and rare variants according to minor allele frequency (MAF). Common varian...
Source: CNS Neuroscience and Therapeutics - Category: Neuroscience Authors: Source Type: research
Clin EEG Neurosci. 2021 Sep 22:15500594211042708. doi: 10.1177/15500594211042708. Online ahead of print.ABSTRACTMild cognitive impairment (MCI) is a clinical diagnosis based on subjective cognitive decline, objective cognitive impairment, and relative preservation of activities of daily living. The diagnosis may be established via clinical interview, collateral history from an informant, and psychometric examination. Various consensus groups have proposed criteria for MCI in Alzheimer's disease (AD), Parkinson's disease, dementia with Lewy bodies, and vascular cognitive impairment. These diagnostic criteria have subtle but...
Source: Clinical EEG and Neuroscience - Category: Neuroscience Authors: Source Type: research
DEMENTIA develops as abnormal proteins clump together in the brain, blocking neurotransmitters from communicating from one another - a classic sign of Alzheimer's disease. Can your risk of this disease be reduced?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Growing up a musically-obsessed child in the 80's, Daryl Hall was one of my biggest inspirations. A masterful, inventive songwriter with an ocean of soul, he set me on the path to being an artist, to never waste a word, and to sing because I mean it. With six number ones and five additional top ten hits throughout the 70's and 80's Daryl Hall and John Oates are the number one duo in music history. Still at the top of his game at 69 years old, Daryl has won legions of new fans with his hit MTV Live show Live From Daryl's House. In February of 2015, at my very sickest from chronic Lyme and Bartonella, after it was missed b...
Source: Science - The Huffington Post - Category: Science Source Type: news
We report a patient with features of atypical dementia and normal pressure hydrocephalus (NPH), who improved dramatically after a single 3-week course of ceftriaxone.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research
Tara and David Geraghty On Dec. 22, three days before Christmas, 55-year-old David A. Geraghty died from complications of a supposedly rarely fatal infection: Lyme disease. As reported in The Valley Breeze, a Lincoln, R.I. newspaper, Geraghty and his family found out conclusively that he has had Lyme disease just one year ago, last December. As was the case for me and is not uncommon in other cases of Lyme disease diagnoses, it was Geraghty and his wife -- not his physicians -- who pushed for investigation into the cause of his illness and ultimately were responsible for discovering that Lyme disease was at the root. Gerag...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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