Cancers, Vol. 13, Pages 2278: Primary Ovarian Mesothelioma: A Case Series with Electron Microscopy Examination and Review of the Literature

Cancers, Vol. 13, Pages 2278: Primary Ovarian Mesothelioma: A Case Series with Electron Microscopy Examination and Review of the Literature Cancers doi: 10.3390/cancers13092278 Authors: Vimercati Cavone Delfino Bruni Maria Caputi Sponselli Rossi Resta Fortarezza Pezzuto Serio Primary ovarian mesothelioma is a rare, aggressive neoplastic disease with a poor prognosis. At onset, the tumor is only rarely limited to the ovaries and usually already widespread in the peritoneum. The rarity of this entity and the difficulties differentiating it from either ovarian carcinoma or peritoneal mesothelioma may lead to frequent misdiagnoses and may raise some concerns about its histogenesis. Thus, reporting such rare cases is fundamental to gain greater awareness of this neoplasm and try to answer unsolved questions. Herein, we described four cases of histological diagnoses of ovarian mesothelioma extrapolated by the regional mesothelioma register of Apulia (southern Italy). In all cases, a detailed medical history was collected according to national mesothelioma register guidelines. A broad panel of antibodies was used for immunohistochemistry to confirm the diagnoses. Moreover, ovarian tissue samples were also examined by transmission and scanning electron microscopy, detecting asbestos fibers and talc crystals in two cases. Because of the few cases described, we reviewed the English literature in the Medline database, focusing on articles about ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research