Biomimetic sponges improve muscle structure and function following volumetric muscle loss

In this study, biomimetic sponges composed of gelatin, collagen, laminin-111, and FK-506 were used for the treatment of VML in a rodent model. We observed that biomimetic sponge treatment improved muscle structure and function while modulating inflammation and limiting the extent of fibrotic tissue deposition. Specifically, sponge treatment increased the total number of myofibers, type 2B fiber cross-sectional area, myosin: collagen ratio, myofibers with central nuclei, and peak isometric torque compared to untreated VML injured muscles. As an acellular scaffold, biomimetic sponges may provide a promising clinical therapy for VML.PMID:33960118 | DOI:10.1002/jbm.a.37212

Source: Biomed Res - May 7, 2021 Category: Research Authors: Gabriel Haas Andrew Dunn Josh Madsen Peter Genovese Hannah Chauvin Jeffrey Au Natalia Ziemkiewicz David Johnson Allison Paoli Andrew Lin Nicholas Pullen Koyal Garg Source Type: research