Leucine-rich repeat-containing G protein-coupled receptor 5 marks different cancer stem cell compartments in human Caco-2 and LoVo colon cancer lines

CONCLUSION: Our findings highlight the presence of a spectrum of different ISC-like compartments in different colon cancer cell lines. Their existence is an important consideration for their screening applications and should be taken into account when interpreting drug screening data. We have generated a portable LGR5-reporter that serves as a valuable tool for the identification and isolation of different colon cancer stem cell populations in colon cancer lines.PMID:33958845 | PMC:PMC8058648 | DOI:10.3748/wjg.v27.i15.1578
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Source Type: research