Efficacy and tolerability of a whey-based, medium-chain triglyceride –enhanced ketogenic formula in children with refractory epilepsy: a retrospective study

Ketogenic metabolic therapy (KMT) is a term coined by Beth Zupac-Kania in 2016 to describe the variety of dietary therapies that restrict carbohydrate intake and liberalize dietary fat intake to stimulate nutritional ketosis [1]. Nutritional ketosis occurs when the body metabolizes fat in the absence of adequate carbohydrates for energy production via glycolysis. A meta-analysis of 38 studies reviewed the therapeutic efficacy of KMT for epilepsy and calculated a weighted success rate of 58.4% (95% CI, 48.7-69.9%), with success defined as a reduction of seizures by at least 50% at 3 months [2].
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Source Type: research