Therapeutic Efficacy of Large Aligned Cardiac Tissue Derived from Induced Pluripotent Stem Cell in a Porcine Ischemic Cardiomyopathy Model
Although induced pluripotent stem (iPS) cell-derived cardiac constructs may have a potential in cardiomyogenesis of a distressed myocardium, obtaining polarity in cardiac constructs, such as via myocyte alignment, may be crucial to achieve a maximum contractile force for better clinical outcomes. We herein hypothesized that transplantation of an aligned cardiac tissue derived from iPS cells has therapeutic effects in a porcine ischemic cardiomyopathy model as a preclinical trial.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Kota Suzuki, Shigeru Miyagawa, Li Liu, Takuji Kawamura, Junjun Li, Xiang Qu, Akima Harada, Koichi Toda, Daisuke Yoshioka, Satoshi Kainuma, Ai Kawamura, Yoshiki Sawa Tags: Original Pre-Clinical Science Source Type: research
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