An Evidence-Based Assessment of Genes in Dilated Cardiomyopathy

Conclusions: In the curation of 51 genes, 19 had high evidence (12 definitive/strong; seven moderate). Notably, these 19 genes only explain a minority of cases, leaving the remainder of DCM genetic architecture incompletely addressed. Clinical genetic testing panels include most high evidence genes, however genes lacking robust evidence are also commonly included. We recommend that high evidence DCM genes be used for clinical practice and to exercise caution when interpreting variants in variable evidence DCM genes.PMID:33947203 | DOI:10.1161/CIRCULATIONAHA.120.053033

Source: Circulation - May 5, 2021 Category: Cardiology Authors: Elizabeth Jordan Laiken Peterson Tomohiko Ai Babken Asatryan Lucas Bronicki Emily Brown Rudy Celeghin Matthew Edwards Judy Fan Jodie Ingles Cynthia A James Olga Jarinova Renee Johnson Daniel P Judge Najim Lahrouchi Ronald H Lekanne Deprez R Thomas Lumbers Source Type: research