High frequency of PIK3CA and TERT promoter mutations in fibromatosis-like spindle cell carcinomas

CONCLUSIONS: Our study showed that PIK3CA and TERT promoter mutations were common genetic features of FLSCCs. These findings contribute to our understanding of FLSCCs biology.PMID:33952589 | DOI:10.1136/jclinpath-2020-207071
Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Source Type: research

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or Breast Screening Pathology European Working Group for Breast Screening Pathology Triple-negative breast cancers (TNBC), as a group of tumours, have a worse prognosis than stage-matched non-TNBC and lack the benefits of routinely available targeted therapy. However, TNBC is a heterogeneous group of neoplasms, which includes some special type carcinomas with a relatively indolent course. This review on behalf of the European Working Group for Breast Screening Pathology reviews the literature on the special histological types of BC that are reported to have a triple negative phenotype and indolent behaviour. These incl...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Int J Clin Exp Pathol. 2021 Mar 1;14(3):355-362. eCollection 2021.ABSTRACTMetaplastic breast carcinoma is a rare invasive breast cancer. Metaplastic breast carcinoma is mainly characterized by an epithelial or mesenchymal cell population mixed with adenocarcinoma. We collected 26 cases of metaplastic breast carcinoma in the First Affiliated Hospital of Bengbu Medical College from 2008 to 2014. Tumor size, tumor grade, vascular invasion, ER/PR status, histologic classification, and HER2/neu status were assessed for all cases and the literature was reviewed. Clinicopathologic characteristics of patients diagnosed with metapl...
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Source Type: research
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