Organisational and clinical approach to osteoporosis in rheumatology: OP-SER-Excellence survey and consensus

Publication date: Available online 7 May 2021Source: Reumatología Clínica (English Edition)Author(s): Antonio Naranjo, Pilar Aguado, Javier de Toro, M. Dolores Toledo, Teresa González, José Rosas, Cristina Campos Fernández, Diana Gavilan, Grupo OsteoResSER
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research

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Cardiovascular disease (CVD) and osteoporosis often occur together, suggesting an association between CVD and bone loss. Similarly, the correlation of bone loss, atherosclerosis, and aortic calcification, especially in patients with chronic kidney disease, exemplifies a bone-vessel connection. In this issue of the JCI, Santhanam et al. investigated the role of the angiogenesis factor platelet-derived growth factor–BB (PDGF-BB) in vascular stiffening. Serum levels of bone-derived PDGF-BB differed between young and aged mice, and in mice fed a high-fat diet (HFD) compared with those fed normal chow. Experiments with ge...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Evidence links osteoporosis and cardiovascular disease but the cellular and molecular mechanisms are unclear. Here we identify skeleton-secreted platelet-derived growth factor–BB (PDGF-BB) as a key mediator of arterial stiffening in response to aging and metabolic stress. Aged mice and those fed high-fat diet (HFD), relative to young mice and those fed normal chow food diet, respectively, had higher serum PDGF-BB and developed bone loss and arterial stiffening. Bone/bone marrow preosteoclasts in aged mice and HFD mice secrete an excessive amount of PDGF-BB, contributing to the elevated PDGF-BB in blood circulation. C...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
We describe here a National Institutes of Health-funded, multicenter, placebo-controlled clinical trial of Fisetin for older adult skilled nursing facility residents who have been, or become, SARS-CoV-2 rtPCR-positive, including the rationale for targeting fundamental aging mechanisms in such patients. Link: https://doi.org/10.1111/jgs.17416
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
J Cell Mol Med. 2021 Oct 15. doi: 10.1111/jcmm.16949. Online ahead of print.ABSTRACTOsteoporosis is an age-related disease characterized by low mineral density, compromised bone strength and increased risk of fragility fracture. Most agents for treating osteoporosis focus primarily on anti-resorption by inhibiting osteoclast activity. Bisphosphonate (BP) is a potent anti-resorptive agent that has been used clinically for decades and is proven to be effective. However, BP has a variety of side effects and is far from being an ideal anti-osteoporosis agent. BP selectively binds to calcium crystals, which are subsequently tak...
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
In conclusion, piRNA-36741 overexpression promoted osteogenic differentiation of BMSCs and mitigated ovariectomy-induced osteoporosis through METTL3-mediated m6A methylation of BMP2 transcripts.PMID:34645714 | DOI:10.18632/aging.203630
Source: Aging - Category: Biomedical Science Authors: Source Type: research
Study Design. Retrospective cohort study. Objective. The aim of this study was to compare different aspects of fusion surgery in patients with osteoporosis with regard to graft subtype and surgical approach. Summary of Background Data. Osteoporosis and chronic lower back pain are common in elderly populations and significantly increase the risk of compression fractures within the spine. Methods. Using the 2016–2017 National Readmission Database we identified 11,086 osteoporotic patients who received lumbar fusion using ICD-10 coding. Information regarding biologic graft type and surgical appr...
Source: Spine - Category: Orthopaedics Tags: EPIDEMIOLOGY Source Type: research
The objective of this study is to investigate the ant...
Source: Journal of Orthopaedic Surgery and Research - Category: Orthopaedics Authors: Tags: Research article Source Type: research
With the increasing incidence of osteoporosis, vitamin K and calcium have been linked to bone mineral density (BMD) and undercarboxylated osteocalcin (UcOC) in many studies, but the results of studies of the c...
Source: Journal of Orthopaedic Surgery and Research - Category: Orthopaedics Authors: Tags: Systematic review Source Type: research
ConclusionApproximately 30% of elderly patients with CT imaging and long-term hospital records showed VFs. Only one-quarter of these patients had VFs mentioned in CT reports. Osteoporosis management could be improved by consequent reporting of VFs in CT, opportunistic bone density measurements, and early involvement of fracture liaison services.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
Am J Physiol Cell Physiol. 2021 Oct 13. doi: 10.1152/ajpcell.00334.2021. Online ahead of print.ABSTRACTChloride transport across cell membranes is broadly involved in epithelial fluid transport, cell volume and pH regulation, muscle contraction, membrane excitability, and organellar acidification. The human genome encodes at least 53 chloride transporting proteins with expression in cell plasma or intracellular membranes, which include chloride channels, exchangers and cotransporters, some having broad anion specificity. Loss of function mutations in chloride transporters cause a wide variety of human diseases, including c...
Source: American Journal of Physiology. Cell Physiology - Category: Cytology Authors: Source Type: research
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