Adult Hereditary White Matter Diseases With Psychiatric Presentation: Clinical Pointers and MRI Algorithm to Guide the Diagnostic Process

CONCLUSIONS: Features such as drug-resistant symptoms, presence of long-standing somatic features, trigger events, consanguinity, and positive family history should orient the clinician toward diagnostic workup to exclude the presence of a genetic white matter disorder. The identification of MRI white matter abnormalities, especially when presenting a specific pattern of involvement, should prompt genetic testing for known forms of genetic leukoencephalopathies.PMID:33951919 | DOI:10.1176/appi.neuropsych.20110294

Source: Journal of Neuropsychiatry and Clinical Neurosciences - May 6, 2021 Category: Psychiatry Authors: Catalina Costei Michaela Barbarosie Genevi ève Bernard Bernard Brais Roberta La Piana Source Type: research