White Matter Abnormalities in Late Onset First Episode Mania: A Diffusion Tensor Imaging Study

CONCLUSIONS: Patients with first episode mania in late life have relevant white matter abnormalities not explained by age, affecting interhemispheric and fronto-limbic networks probably related to executive functioning and emotional processing, at the level of the corpus callosum and the uncinate fasciculus. The etiology of this white matter loss of integrity in patients with late-onset mania is yet to be explored.PMID:33879344 | DOI:10.1016/j.jagp.2021.03.007

Source: The American Journal of Geriatric Psychiatry - April 21, 2021 Category: Psychiatry Authors: Jesus Ram írez-Bermúdez Oscar Marrufo-Melendez Cecilia Berlanga-Flores Adilia Guadamuz Carmen Atriano Roger Carrillo-Mezo Patricia Alvarado Rafael Favila Jesus Taboada Camilo Rios Maria Yoldi-Negrete Ramiro Ruiz-Garcia Mauricio Tohen Source Type: research