Zinc attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury by activating Nrf2/GPX4 defense pathway

CONCLUSION: Zinc promoted the degradation of oxidative stress products and lipid peroxides through the NRF2/HO-1 and GPX4 signaling pathways to inhibit ferroptosis in neurons.PMID:33951302 | DOI:10.1111/cns.13657

Source: CNS Neuroscience and Therapeutics - May 5, 2021 Category: Neuroscience Authors: Ming-Hao Ge He Tian Liang Mao Dao-Yong Li Jia-Quan Lin Heng-Shuo Hu Shuo-Cheng Huang Chuan-Jie Zhang Xi-Fan Mei Source Type: research