Cord blood levels of interleukin-10 decrease in neonates with increased birth weight: novel implications of the cytokine network in early obesity

Conclusion: In conclusion, this work demonstrates for the first time that cord blood IL-10 decreases as birth weight increases in infants born at term and might help to improve early recognition of newborns at higher risk of developing obesity in childhood or adulthood.What is Known:•Reduction in interleukin-10 levels has been associated with obesity in adolescents and adults but not newborns.•The number of neonates with excess birth weight has alarmingly increased in the last 30 years.What is New:•We demonstrate that umbilical cord blood levels of interleukin-10 clearly decrease as birth weight increases.•Interleukin-10 and interferon-gamma integrate a cytokine network that might play a role in obesity in infants.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research