Mineralocorticoid receptor modulation by dietary sodium influences NAFLD development in mice

CONCLUSION: We identified in two experimental models of NAFLD that High-Na+ diet content is associated to lower serum aldosterone levels and hepatic MR downregulation, associated to decreased steatosis and reduced de novo hepatic lipogenesis, proinflammatory and profibrotic markers. Decreased activation of hepatic MR seems to generate beneficial downstream inhibition of lipogenesis in experimental NAFLD.PMID:33940220 | DOI:10.1016/j.aohep.2021.100357

Source: Annals of Hepatology - May 3, 2021 Category: Gastroenterology Authors: Daniel Cabrera Isabel Rao Fabiola Raasch Nancy Solis Margarita Pizarro Mariela Freire Diego S áenz De Urturi Carolina A Ram írez Nicol ás Triantafilo Jonathan Le ón Arnoldo Riquelme Francisco Barrera Rene Baudrand Patricia Aspichueta Marco Arrese Juan Source Type: research