Understanding the Immuno-biology of Oesophageal Adenocarcinoma: Towards Improved Therapeutic Approaches

Oesophageal adenocarcinoma (OAC) is a lethal cancer with a rising incidence globally [1]. Although oesophageal squamous cell carcinoma (OSCC) remains the dominant subtype worldwide due to its predominance across the “oesophageal cancer belt” through China, Central Asia, and Northern Iran as well as Eastern Africa, the incidence of OAC is rising in these populations also [2, 3]. The main risk factors for OAC include advancing age, male sex, obesity, and gastro-oesophageal reflux disease (GORD), and changes i n these epidemiological risk factors across both Western populations and through the oesophageal cancer belt may explain changing incidence rates [2].
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Tags: Tumour Review Source Type: research