Management of musculoskeletal complications in patients with hemophilia: literature review and expert recommendations

Cardiovasc Hematol Disord Drug Targets. 2021 Apr 27. doi: 10.2174/1871529X21666210427134232. Online ahead of print.ABSTRACTIn people with hemophilia, hematological prophylaxis during childhood and adolescence could elude the occurrence of musculoskeletal complications (in joints and muscles) if the concentration of the defective factor is averted from decreasing under 1% of normal. Prompt management is of capital significance as the juvenile skeleton is hypersensitive to the adverse events of the disease; intense structural defects might appear rapidly. Important articular bleeds and inveterate hypertrophy of the articular synovial membrane must be treated vigorously to preclude joint degeneration (hemophilic arthropathy). At the moment that extreme joint disease is in place with intense affliction, the goal must be to reestablish activity whilst at the same time reducing the peril to the patient. Articular debridement is an efficacious surgical technique to accomplish this goal, particularly around the knee or ankle, and may be contemplated to be a backup to ankle arthrodesis or ankle or knee replacement in patients of younger age. Eventually joint replacement can commonly reestablish both articular mobility and function in an unhealthy articulation.PMID:33906595 | DOI:10.2174/1871529X21666210427134232
Source: Cardiovascular and Hematological Disorders Drug Targets - Category: Drugs & Pharmacology Authors: Source Type: research