Premedication with ketamine or propofol for less invasive surfactant administration (LISA): observational study in the delivery room

Conclusion: Pending results from prospective trials, these findings suggest that ketamine or propofol can be used for premedication before LISA, as they show comparable efficacy and tolerance.Trial registration: This study was recorded on the National Library of Medicine registry (https://clinicaltrials.gov/ Identifier: NCT03705468).What is Known?• Less invasive surfactant administration (LISA) is increasingly used in spontaneously breathing premature infants supported with continuous positive airway pressure, but few data are available to guide adequate premedication for this procedure.What is New?• This observational study of 114 neonates, all less than 30-week gestational age and requiring surfactant without endotracheal tube in the delivery room, suggested that ketamine or propofol can be used for premedication before LISA with comparable efficacy and tolerance.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research