Role of gastric motility in weight gain after subthalamic nucleus stimulation in Parkinson's disease

Bilateral deep brain stimulation of the subthalamic nucleus (STN-DBS) is now considered as a gold standard surgical treatment for advanced forms of Parkinson's disease (PD), with dramatic improvement in parkinsonian disability. Rapid and significant body weight gain represents one of the most frequent side effects of STN-DBS, that could lead to increased cardiovascular and metabolic diseases [1 –3]. The mechanism of this weight gain is not fully understood and various factors have been envisaged such as decreased resting energy expenditure (REE), linked to the decreased parkinsonian disability and/or a local effect of STN-DBS on the hypothalamic centres with changes in central regulation of energy metabolism, secretion or integration of orexigenic or anorexigenic signals, and eating behaviour by integrating circulating energy-related signals like leptin, ghrelin, or nutrients [2,4].
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - Category: Neurology Authors: Source Type: research